| 纳米羟基磷灰石人工骨的生物相容性研究 |
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| 引用本文： | 江捍平,王大平,阮建明,朱伟民. 纳米羟基磷灰石人工骨的生物相容性研究[J]. 中国现代医学杂志, 2005, 15(10): 1477-1480 |
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| 作者姓名： | 江捍平 王大平 阮建明 朱伟民 |
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| 作者单位： | 1. 深圳市急救医疗中心,广东,深圳,518035
2. 中南大学冶金粉末国家重点实验室,湖南,长沙,410083 |
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| 基金项目： | 深圳市科技计划项目资助(200304219) |
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| 摘 要： | 目的 评价新型纳米羟基磷灰石人工骨的生物相容性，从而为其在骨缺损修复领域中的临床运用提供依据。方法 分别进行急性毒性试验、热原试验、皮内试验、肌肉植入试验、骨植入试验等生物相容性试验。结果 这种纳米羟基磷灰石人工骨材料无毒，无热原性，植入兔肌肉后逐渐发生降解。结论 此纳米羟基磷灰石人工骨材料具有良好的生物相容性。
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| 关 键 词： | 羟基磷灰石 纳米材料 人工骨 生物相容性 |
| 文章编号： | 1005-8982(2005)10-1477-04 |
Biocompatibility study of nano-hydroxyapatite artificial bone |
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| JIANG Han-ping,WANG Da-ping,RUAN Jian-ming,ZHU Wei-min. Biocompatibility study of nano-hydroxyapatite artificial bone[J]. China Journal of Modern Medicine, 2005, 15(10): 1477-1480 |
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| Authors: | JIANG Han-ping WANG Da-ping RUAN Jian-ming ZHU Wei-min |
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| Affiliation: | JIANG Han-ping1,WANG Da-ping1,RUAN Jian-ming2,ZHU Wei-min1 |
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| Abstract: | [Objective] To study the biocompatibility and safety of nano-hydro xyapatite artificial bone for the clinical use in the bone's reconstruction fiel d. [Method] Evaluated the biocompatibility through the experiments including a cute systemic toxicity test,pyrogen,intracutaneous test and long-term muscle and bone implant test. [Results] All results indicated that the material had no t oxicity,no irritation to skin and did not contain the pyrogen material. [Conclu sion] The nano- hydroxyapatite (nano-HA) artificial bone possesses excellent bi ocompatibility. |
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| Keywords: | hydroxyapatite nano-material artificial bone biocompatibility |
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