K-ras及hMSH2蛋白在45岁以下妇女子宫内膜癌中的表达

[目的]探讨K-ras及hMSH2蛋白在年轻妇女子宫内膜癌(EC)组织中的表达及相关性.[方法]选取因子宫病变行子宫全切的标本66例,其中EC 42例、子宫内膜非典型增生6例、正常子宫内膜18例.测定其内膜组织中K-ras及hMSH2的表达.[结果]①在正常子宫内膜、子宫内膜不典型增生及EC中K-ras均呈高表达,且差...

Expression of K-ras and hMSH2 in Endometrial Carcinoma in Women Under 45 Years Old

[Objective] To study the expressions and relationship between K ras and hMSH2 in endometri al carcinoma（EC） in young women under 45 years old. [Methods] Totally 66 uterine specimens which were excised for uterine diseases, including 42 cases of EC, 6 cases of atypical endometrial hyperplasia and 18 cases of normal endometrium, were selected. The expressions of K-ras and hMSH2 in the tissues of endometrium were detected. [Results] The expressions of K-ras were higher in normal endometrium, atypical endometrial hyperplasia and endometrial carcinoma, and there were significant differences among them（ P〈0.05）. The expression rates of hMSH2 were 44. 44% 33.33% and 73.81%,respectively, and there were also significant differences（ P〈0. 005）. But the expressions of K-ras and hMSH2 had no relationship with clinical stages, histological grades, myometrial invasion depth and lymphatic metastasis whether or not（ P〉0.05）. In endometrial carcinoma group, there was positive correlation between K ras and hMSH2 （rs=0. 351, P〈0.05）. [Conclusion] The expression of K-ras occurs in the early stage of endometrial carcinoma and has no relation with prognosis. The expression of hMSH2 is related with the proliferation of tumor cells.