小细胞肺癌合并低钠血症的临床特点及预后分析

目的:探讨小细胞肺癌合并低钠血症患者的临床特点及预后.方法:对中南大学湘雅二医院肿瘤科2000年1月至2007年12月间收治的158例小细胞肺癌患者进行回顾性分析.结果:小细胞肺癌患者中合并低钠血症者67例,占42.4%,其中位生存期为7.6个月;血钠正常组中位生存期为14.1个月,两者比较差异有统计学意义(P<0.0...

Clinical features and prognosis analysis of small-cell lung cancer complicated with hyponatremia

ObjectiveTo evaluate the clinical features and prognosis of small cell lung cancer (SCLC) complicated with hyponatremia. MethodsThe clinical data of 158 patients with SCLC of the Second Xiangya Hospital from January 2000 to December 2007 were studied retrospectively. ResultsThe incidence rate of hyponatremia in SCLC was 42.4%(67/158). The median survival time was 7.6 months in patients with subnormal serum sodium, and 14.1 months in patients with normal values. There was significantly different between 2 groups (P<0.001).  The patients who did not fully regain normal values of serum sodium, had poorer survival (6.2 months) compared with the patients with normal serum sodium (10.3 months， P=0.044). ConclusionThe incidence rate of hyponatremia in SCLC is high. The prognosis of SCLC with hyponatremia is very poor, especially in those who can not regain normal values of serum sodium after the treatment. So diagnosis and treatment at early stage are very important.