鬼箭羽对2型糖尿病血瘀证大鼠血糖及血液流变学的影响

目的:研究鬼箭羽对2型糖尿病血瘀证大鼠血糖及血液流变学的影响.方法:喂饲高脂饲料加链脲佐菌素腹腔注射造成2型糖尿病模型后,再注射强的松龙和肾上腺素制备成中医血瘀证大鼠模型,从而得到2型糖尿病血瘀证中医病症大鼠模型.随机将制模成功的大鼠分为模型组、鬼箭羽组、优降糖组 3 组,并设立空白对照组.鬼箭羽组给予鬼箭羽灌胃,优降...

Effect of Euonymus alatus on the blood glucose and hemorheology in the rat model of Type 2 diabetes mellitus with blood stagnation

ObjectiveTo explore the effect of Euonymus alatus on the blood glucose and hemorheology in rat model of Type 2 diabetes mellitus with blood stagnation (DMBS). MethodsHigh fat diet with streptozocin was used to establish the rat model of Type 2 diabetes mellitus, followed by the prednisolone and adrenaline muscle injection to obtain DMBS. DMBS rats were divided into a DMBS group (treated with saline gavage), an Euonymus alatus group (treated with Euonymus alatus gavage), and a glybenzoylamide group (treated with glybenzoylamide gavage).A blank group was treated with saline gavage. The experiment lasted 4 weeks, followed by the evaluation of rats’ behavior, and dection of fasting blood glucose and hemorheology. ResultsCompared with DMBS rats, the symptoms of polydipsia and diuresis in Euonymus alatus rats were improved, with increased body weight （P＜0.05), better fur and mental state, increased resistance for being caught, and reduced tongue stagnation. Compared with DMBS group, though body weight increased, resistance for being caught decreased in the glybenzoylamide group with bad fur and mental state,and tongue stagnation. As to the fasting blood glucose, there was significant difference between the Euonymus alatus group and the DMBS group （P＜0.05）. As to the hemorheology, including whole blood viscosity (shear rates 1,5,50, and 100 s－1), plasma viscosity, and hematocrit, the Euonymus alatus rats had a better efficacy than DMBS rats and glybenzoylamide rats (P＜0.05 or P＜0.01）. ConclusionEuonymus alatus can reduce the fasting blood glucose of DMBS and improve blood stagnation.