持续气道正压通气对老年OSAHS合并2型糖尿病患者胰岛素抵抗的影响

[目的]探讨持续气道正压通气(CPAP)对老年合并2型糖尿病的阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者胰岛素抵抗(IR)的影响.[方法]选择老年合并2型糖尿病的OSAHS患者52例,通过3个月的CPAP治疗,观察治疗前后反映IR的稳态模式评估(HOMA)指数变化.[结果]CPAP治疗3个月后呼吸暂停/低通气指数...

Effect of Continuous Positive Airway on Insulin Resistance in Elderly Patients with Type 2 Diabetes and OSAHS

[Objective]To explore the effect of continuous positive airway pressure（CPAP） on insulin resist ance（IR） in elderly patients with type 2 diabetes and obstructive sleep apnea hypopnea syndrome（OSAHS）. [Methods] Fifty-two elderly patients with type 2 diabetes and OSAHS were enrolled in this study. All patients received CPAP treatment for 3 months. The change of homeostasis model assessment（HOMA） index reflecting IR was observed before and after treatment. [Results] After 3 months of CPAP treatment, the apnea/hypopnea index （AHI） and miniSpO2 were improved significantly compared with that before treatment（ P 〈0.01）. The HOMA index was significantly decreased after 3 months of CPAP treatment compared with that before treatment（3.62±0.86 vs 1.98±0.78, P 〈0.01）. [Conclusion]CPAP treatment can significantly improve the IR in elderly patients with type 2 diabetes and OSAHS.