复方抗溃疡颗粒抗实验性胃溃疡作用研究

目的:研究复方抗溃疡颗粒抗实验性溃疡的作用。方法:采用小鼠水浸应激法、大鼠幽门结扎法、醋酸致大鼠胃溃疡法建立动物胃溃疡模型,观察复方抗溃疡颗粒对胃溃疡的保护作用;小鼠扭体法观察复方抗溃疡颗粒的镇痛作用。以豚鼠肠道活动力为指标,观察复方抗溃疡颗粒对回肠平滑肌收缩的影响。结果:复方抗溃疡颗粒对小鼠水浸应激性溃疡、结扎大鼠幽门引起的溃疡和醋酸致大鼠胃溃疡均有明显的保护作用,能降低大鼠胃溃疡数,减少溃疡面积;可降低醋酸致小鼠扭体反应的次数;能兴奋豚鼠回肠平滑肌。结论:复方抗溃疡颗粒具有抗实验性胃溃疡的作用。该作用可能与其解痉作用和镇痛作用有关。

Effect of Compound Kangkuiyang Granula on Eexperimental Gastric Ulcer

Objective:To study on the effect of Compound Kangkuiyang Granula on experiment gastric ulcer.Method:The rat gastric ulcer models was induced by water immersing stress,ligation of pylorus and acetic acid;analgesia action was investigated with acetic acid writhing test in mice;the guinea pig intestinal contraction amplitude and inhibition rate were regarded as an indicators to observe the influence of different concentrations of Compound Kangkuiyang Granula on ileum smooth muscle contraction.Result:Compound Kangkuiyang Granula could markedly inhibit the stress gastric ulcer,ligation of pyloms gastric ulcer and acetic acid induced gastric ulcer;could inhibite writhing test in mice,and excited ileum smooth muscle.Conclusion:Compound Kangkuiyang Granula possessed counteraction on gastric ulcer.