| 重组腺相关病毒载体在心血管疾病基因治疗中的应用 |
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| 引用本文： | 张梅珍,袁洪,黄志军,胡帆.重组腺相关病毒载体在心血管疾病基因治疗中的应用[J].中南大学学报(医学版),2011,36(2):178-184. |
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| 作者姓名： | 张梅珍 袁洪 黄志军 胡帆 |
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| 作者单位： | 中南大学1.湘雅三医院临床药理中心； 2.药学院, 长沙 410013 |
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| 摘 要： | 腺相关病毒体是一种有DNA缺陷的非致病性细小病毒,重组腺相关病毒载体(rAAV)源于非致病的野生型腺相关病毒,具有安全性好、宿主范围广等优点.rAAV已成为基因治疗研究的热点,特别是在心血管疾病机制探讨和治疗研究中应用广泛.在过去几十年里,rAAV在高血压、心力衰竭、动脉硬化和心肌梗死等心血管疾病基因治疗中成果显著.
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| 关 键 词： | 重组腺相关病毒载体 心血管疾病 基因治疗 |
Recombinant-adeno-associated viral vector-mediated gene therapy for cardiovascular diseases |
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| ZHANG Meizhen,YUAN Hong,HUANG Zhijun,HU Fang.Recombinant-adeno-associated viral vector-mediated gene therapy for cardiovascular diseases[J].Journal of Central South University (Medical Sciences)Journal of Central South University (Medical Sciences),2011,36(2):178-184. |
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| Authors: | ZHANG Meizhen YUAN Hong HUANG Zhijun HU Fang |
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| Institution: | 1. Center of Clinical Pharmacology, Third Xiangya Hospital;
2. School of Pharmaceutical Sciences, Central South University, Changsha 410013, China |
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| Abstract: | Adeno-associated virus is a kind of DNA defective parvovirus which is non-pathogenic. Recombinant-adeno-associated virus vector comes from wild-type non-pathogenic adeno-associated virus and is highly secure, and it also has the advantages of broad host range. Recombinant-adeno-associated virus vector has become a hot spot for gene therapy and is widely used in gene therapy for cardiovascular diseases, especially for hypertension, heart failure, arteriosclerosis, and myocardial infarction. |
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| Keywords: | recombinant-adeno-associated virus vector cardiovascular disease gene therapy |
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