肛周尖锐湿疣患者外周血T细胞亚群及NK细胞的分析

目的：了解肛周尖锐湿疣T细胞亚群及NK细胞有无异常。方法：应用流式细胞仪检测尖锐湿疣患者及正常对照组T细胞亚群以及NK细胞。结果：与对照组比较患者组CD3细胞无显著性改变，CD4细胞显著降低，CD4／CD8值降低，NK细胞较正常对照组显著降低，CD8细胞显著升高。结论：尖锐湿疣患者细胞免疫功能缺陷以及NK细胞数的下降可能是导致尖锐湿疣易发病的原因。

Analysis of T lymphocyte subsetes and NK cell in peripheral blood of perianal condyloma acuminatae patients

Objective:To analyze the effects of T lymphocyte subsetes and NK cell in peripheral blood on perianal condylomtacuminatae.Methods:Tlymphocyte subsetes and NK cell weredetected quantitatively by flow cytometry in patients with Condyloma acurainatae and the controls.Results:No significant diference Wasfound in CD 3 cell counts between the patients with condylomaacuminatae and the controls.However,significant decrease of CD 4cell,CD 4/CD 8 ration,NK cell were found in the patients with condyloma acuminatae than those in the controls,and significant increase of CD 8 wasfound in the patients with condyloma acuminatae than those in the controls. Conclusions:The results indicate that the defect of the cellular immunofunction and decreased counts of NK cell migh berelated to the pathogenesis of condyloma acuminatae.