Synthesis and 5-HT receptors binding studies of some 3-substituted-2-(4-methyl-1-piperazinyl)-4-phenylquinolines. |
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| Authors: | M Anzini A Cappelli S Vomero G Campiani A Cagnotto M Skorupska |
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| Affiliation: | Dipartimento Farmaco Chimico Tecnologico-Università, Siena, Italy. |
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| Abstract: | The syntheses of some 3-substituted-2-(4-methyl-1-piperazinyl)-4-phenylquinolines are reported. The title compounds were tested for their potential activities on 5-HT receptor subtypes and 5-HT uptake site; compounds 4b-d showed micromolar affinity for 5-HT3 and 5-HT uptake site. |
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