Failure of cyclosporin-A to induce immunological unresponsiveness to nerve allografts |
| |
Authors: | Andrew A. Zalewski Adarsh K. Gulati |
| |
Affiliation: | Laboratory of Neurochemistry, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20205 USA |
| |
Abstract: | Although some allografts bearing major and minor transplantation antigens can survive after the cessation of immunosuppression with cyclosporin-A (Cy-A), nerve allografts do not. In an attempt to induce immunological unresponsiveness to nerve allografts, we used grafts containing only minor transplantation antigens and varied the duration of Cy-A therapy from 2 to 12 weeks. Our results demonstrated that nerve allografts survived in rats during Cy-A therapy, but when the drug administration ceased, the allografts were rejected. Other factors besides the degree of histoincompatibility and duration of Cy-A treatment must be involved in determining whether or not unresponsiveness develops to allografts after Cy-A withdrawal. We conclude that nerve allograft immunosuppression generated by Cy-A requires regular administration of the drug. |
| |
Keywords: | Cy-A cyclosporin-A FR Fischer LE Lewis PAS-hematoxylin periodic acid-Schiff hematoxylin |
本文献已被 ScienceDirect PubMed 等数据库收录! |