| 坎地沙坦对轻中度高血压患者颈动脉重构的影响 |
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| 引用本文： | 姜坚.坎地沙坦对轻中度高血压患者颈动脉重构的影响[J].实用诊断与治疗杂志,2009,23(4). |
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| 作者姓名： | 姜坚 |
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| 作者单位： | 上海交通大学医学院附属新华医院急诊内科,上海市,200092 |
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| 摘 要： | 目的:观察以坎地沙坦为基础的降压治疗对原发性高血压患者颈动脉内中膜厚度、内中膜厚度/血管内径的影响,探讨坎地沙坦降血压以外的心血管保护作用。方法:63例1～2级原发性高血压患者,超声检测其颈动脉的内中膜厚度和内径,给予以坎地沙坦为基础的降压治疗,根据患者血压的反应加用小剂量的氢氯噻嗪,6个月后超声复查颈动脉情况。结果:63例原发性高血压患者,收缩压在治疗前为(155.08±7.926)mm Hg,治疗6个月后为(128.44±3.509)mm Hg;舒张压治疗前(96.06±4.586),治疗6个月后(81.24±4.257)mm Hg;心率治疗前为(77.21±7.565)次/min,治疗6个月后为(72.79±3.976)次/min,治疗前、后比较差异有统计学意义(P<0.05)。治疗6个月后,内中膜厚度较治疗前减少(0.088±0.046)mm,内径较治疗前增加(0.138±0.069)mm,内中膜厚度/血管内径较治疗前减少(0.032±0.020),差异均有统计学意义(P<0.01)。结论:以坎地沙坦为基础,加用小剂量利尿剂的降压方案具有良好的临床效果,具有确切的改善动脉粥样硬化作用。
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| 关 键 词： | 高血压 坎地沙坦 颈动脉内膜-中层厚度 |
Influence of candesartan on carotid artery remodeling in patients with mild to moderate hypertension |
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| JIANG Jian.Influence of candesartan on carotid artery remodeling in patients with mild to moderate hypertension[J].Journal of Practical Diagnosis and Therapy,2009,23(4). |
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| Authors: | JIANG Jian |
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| Abstract: | Objective To investigate the effect of candesartan on intima-media thickness and IMT/R in the essential hypertension patients.Methods Sixty-three patients with mild to moderate hypertension were given the antihypertensive therapy based on candesartan and added low dose hydrochlorothiazide according to their blood pressure response.Carotid intima-media thickness and the inner diameter of the lumens were compared before and after 6 months' antihypertensive therapy.Results After treatment,systolic and diastoli... |
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| Keywords: | Essential hypertension candesartan carotid intima-media thickness |
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