Computational analysis of the effect of the type of LVAD flow on coronary perfusion and ventricular afterload |
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| Authors: | Ki Moo Lim In Su Kim Seong Wook Choi Byung Goo Min Yong Soon Won Heon Young Kim and Eun Bo Shim |
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| Institution: | (1) Department of Mechanical and Biomedical Engineering, Kangwon National University, Hyoja-dong, Chuncheon, Gangwon-do, Republic of Korea;(2) Department of Thoracic and Cardiovascular Surgery, College of Medicine, Soonchunhyang University, Bucheon, Gyeonggi-do, Republic of Korea |
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| Abstract: | We developed a computational model to investigate the hemodynamic effects of a pulsatile left ventricular assist device (LVAD)
on the cardiovascular system. The model consisted of 16 compartments for the cardiovascular system, including coronary circulation
and LVAD, and autonomic nervous system control. A failed heart was modeled by decreasing the end-systolic elastance of the
ventricle and blocking the mechanism controlling heart contractility. We assessed the physiological effect of the LVAD on
the cardiovascular system for three types of LVAD flow: co-pulsation, counter-pulsation, and continuous flow modes. The results
indicated that the pulsatile LVAD with counter-pulsation mode gave the most physiological coronary blood perfusion. In addition,
the counter-pulsation mode resulted in a lower peak pressure of the left ventricle than the other modes, aiding cardiac recovery
by reducing the ventricular afterload. In conclusion, these results indicate that, from the perspective of cardiovascular
physiology, a pulsatile LVAD with counter-pulsation operation is a plausible alternative to the existing LVAD with continuous
flow mode.
An erratum to this article can be found at |
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| Keywords: | Left ventricular assist device Cardiovascular system model Physiological performance of LVAD Heart failure |
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