2型糖尿病肾病的危险因素分析

目的: 探讨2型糖尿病肾病发生的危险因素.方法: 根据24 h尿微量白蛋白(UAlb)定量检测结果,将120例2型糖尿病患者分为2型糖尿病(DM)组60例和2型糖尿病并发糖尿病肾病(DN)组60例,观察2组患者的年龄、病程、收缩压(SBP)、舒张压(DBP)、体质量指数、空腹血糖(FPG)、糖化血红蛋白(HbA1c)、三酰甘油(TC)、总胆固醇(TG)等指标的差异,并采用多因素非条件logistic回归分析DN与各因素的相关性.结果: DN组患者的病程较DM组长(P< 0.01),年龄、SBP、DBP和FPG均高于DM组(P< 0.05～P< 0.01);logistic回归分析显示:病程、SBP、DBP、HbA1c、TG和TC均为DN发生的独立危险因素(P< 0.01).结论: 年龄、病程、高血糖、高血压及脂代谢紊乱是2型糖尿病肾病发生的危险因素.

Analysis of the risk factor of diabetic nephropathy in patients with type 2 diabetes mellitus

Objective: To investigate the risk factors of diabetic nephropathy in patients with type 2 diabetes mellitus.Methods: One hundred and twenty type 2 diabetic patients were divided into type 2 diabetes mellitus group(DM group,60 cases) and diabetic nephropathy group(DN group,60 cases) according to the level 24 h urine micro albumin(UAlb).The age,course of disease,and levels of blood pressure,body mass index(BMI),fasting plasma glucose(FPG),glycosylated hemoglobin A1c(HbA1c),triglyceride(TC) and total cholesterol(TG) in all cases were observed.The correlations of DN with each factor were analyzed using multi-factor unconditioned logistic regression analysis.Results: The course of disease in DN group was longer than that in DM group(P< 0.01).Compared with DM group,the means of age,and levels of SBP,DBP and FPG in DN group were higher(P< 0.01 to P< 0.05).Logistic regression analysis showed that the course of disease,SBP,DBP,TG and TC were the independent risk factor of DN(P< 0.01).Conclusions: Age,course of disease,hyperglycaemia,hypertension and dyslipidemia are the risk factors of type 2 diabetic nephropathy.