| 电针对脊髓损伤大鼠神经生长因子和神经功能的影响 |
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| 引用本文： | 杜旭,王瑞辉.电针对脊髓损伤大鼠神经生长因子和神经功能的影响[J].针灸临床杂志,2009,25(2). |
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| 作者姓名： | 杜旭 王瑞辉 |
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| 作者单位： | 陕西中医学院,陕西,咸阳,712046 |
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| 摘 要： | 目的:观察电针对脊髓损伤(SCI)大鼠脑源性神经生长因子(BDNF)和神经功能活动的影响。方法:48只大鼠平均分为4组,采用改良的Allen’s造模方法建立大鼠SCI模型,电针对照组取"大椎"、"命门"和"夹脊穴"两组穴位交替电针治疗。7天后,通过取各组大鼠脊髓采用免疫组化法测定BDNF的表达水平和分析BBB行为记分法进行各组比较。结果:电针治疗组与甲基强的松龙组大鼠治疗后后肢运动功能改善,非常显著强于模型对照组(P<0.05),而显著差于空白对照组(P<0.01);两组BDNF阳性细胞数非常显著强于模型对照组和空白对照组(P<0.01),但组间没有显著性差异(P>0.05)。结论:电针治疗可明显增强SCI后BDNF的表达,促进SCI后神经的修复与再生,从而促进肢体功能的恢复。
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| 关 键 词： | 电针 脊髓损伤 神经生长因子 神经功能 |
Effect of electroacupuncture on brain derivd neurotrophic factor and nerve function of spinal cord injury rats |
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| DU Xu,WANG Rui-hui.Effect of electroacupuncture on brain derivd neurotrophic factor and nerve function of spinal cord injury rats[J].Journal of Clinical Acupuncture and Moxibustion,2009,25(2). |
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| Authors: | DU Xu WANG Rui-hui |
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| Institution: | DU Xu; WANG Rui-hui Author s address:Shanxi College of Chinese Medicine; Xianyang 712046; China; |
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| Abstract: | Objective:To observation the effect on brain derivd neurotrophic factor(BDNF) and nerve function of spinal cord injury(SCI) rats by electroacupuncture.Methods:we set up SCI rat model by using improved Allen s model building method.48 rats were given into 4 groups,acupoint s alternative electroacupuncture treatment in Dazhui,Mingmen and Jiaji.7 days later,we abstracted rats spinal cord measured expressions of BDNF by immunohistochemistry method and analysizing BBB behavior scoring,to be compared with each g... |
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| Keywords: | Electroacupuncture Spinal cord injury Derivd neurotrophic factor |
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