| 苦菜总黄酮对实验性肝损伤的保护作用 |
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| 引用本文： | 卢新华,陈虎云,戴俊,熊燕.苦菜总黄酮对实验性肝损伤的保护作用[J].中国现代医学杂志,2002,12(3):8-9. |
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| 作者姓名： | 卢新华 陈虎云 戴俊 熊燕 |
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| 作者单位： | 1. 湖南省郴州医学高等专科学校,423000
2. 中南大学湘雅医学院药理教研室 |
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| 摘 要： | 目的：观察总菜总黄酮对实验性肝损伤模型的保护作用。方法：用四氯化致碳小鼠肝损伤模型，以GPT，GOT为指标；用乙醇致小鼠肝损伤模型，以GPT，GSH为指标，分析苦菜总黄酮的保肝效应。结果：苦菜总黄酮能使四氯化致所致GPT，GOT下降，能使乙醇所致GPT值下降，减轻乙醇所致肝脏GSH的耗竭，能明显降低四氯化碳所致小鼠肝组织的病理改变。结论：苦菜总黄酮对四氯化碳、乙醇所致的肝损伤有明显的保护作用，可能与苦菜总黄酮减少肝脏GSH耗竭、抑制肝脂质过氧化作用有关。
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| 关 键 词： | 苦菜总黄酮 肝损伤 GSH 保肝作用 |
| 修稿时间： | 2001年10月11 |
PROTECTIVE EFFECT OF BITTER VEGETABLE FLAVONOIDS ON EXPERIMENTAL LIVER INJURY |
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| Lu Xinhua,Cheng Huyun,Dai Jun,et al..PROTECTIVE EFFECT OF BITTER VEGETABLE FLAVONOIDS ON EXPERIMENTAL LIVER INJURY[J].China Journal of Modern Medicine,2002,12(3):8-9. |
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| Authors: | Lu Xinhua Cheng Huyun Dai Jun |
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| Institution: | Lu Xinhua,Cheng Huyun,Dai Jun,et al. Chenzhou Medical College,423000 |
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| Abstract: | Objective:To determine the protective effect of bitter vegetable Flavonoids (BVF) on experimental liver injury.Methods:The observed target was GPT and GOT on experimental liver injury in mice induced by CCl 4,GPT and GSH on experimental liver injury induced by alcohol,in order to analyse the protective effects of BVF.Results:GPT and GOT induced by CCl 4 were significantly inhibited by BVF,GPT induced by alcohol GPT were significantly lowered by BVF,the loss of GSH were inhibited,and the degeneration and necrosis of liver cells in mice induced by CCl 4 were ameliorated.Conclusions:BVF has signifcantly protective effect on experimental liver injury induced by CCl 4 and alcohol.These findings suggest that the protective effect of BVF on experimental liver injury is related to increasing the GSH concentration and impeding elevation of LPO in liver. |
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| Keywords: | BVF Liver Injury GSH Protective Action |
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