孟鲁司特治疗支气管哮喘急性发作的临床疗效观察

目的了解孟鲁司特治疗支气管哮喘急性发作的临床效果。方法将支气管哮喘急性发作患者76例随机分为两组，实验组39例，对照组37例；对照组常规吸入β^2受体激动剂、糖皮质激素吸入或静点、二羟丙茶碱口服或静点。实验组在相同对照组治疗基础上，加用LT调节剂孟鲁司特10mg，一次／日，口服。治疗前和治疗后第2天、第4天分别观察症状、体征及动脉血PaO2变化。结果治疗前两组患者均为支气管哮喘急性发作，动脉血PaO2平均值比较差异无统计学意义；治疗后第2天、第4天，两组症状、体征缓解率比较，动脉血PaO2值，两组比较差异有统计学意义。结论LT调节剂孟鲁司特治疗支气管哮喘急性发作具辅助疗效，可加速缓解哮喘症状、缩短住院日期。

Clinical research on the treatment of acute attack of bronchial asthma with montelukast

Objective To study the treatment of acute attack of bronchial asthma with montelukast. Methods 76 Patients were separated into two groups. The control group （n = 37 ） were given conventional therapy such as β^2 receptor agonist, cortical hormone, diprophylline transfusion, vein-inputting etc. Besides the conventional therapy, the experiement group （n = 39 ） were given montelukast 10 mg/day. The symptoms and signs, the arterial blood gas were recorded before the treatment and on the 2 nd, 4 th day after the treatment. The data were analyzed. Results Before the treatment, all the patients of the two groups were attacked by bronchial asthma. Mean PaO2 of the two groups was compared and the difference was not significant. There was statistical difference between the groups the rate of perfect effective and in the PaO2 on the 2nd, 4th day after the treatment. Conclusion Montelukast has quick effect on acute attack of bronchial asthma, which may relieve asthma symptoms and shorten the curse of hospital stay.