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炎症反应对接受PCI治疗的非ST段抬高ACS患者造影剂肾病的影响
引用本文:梁海峰,杨明,韩凌,高亢,陈萍,李晓红,马铮. 炎症反应对接受PCI治疗的非ST段抬高ACS患者造影剂肾病的影响[J]. 微循环学杂志, 2013, 23(1): 21-23,5,1
作者姓名:梁海峰  杨明  韩凌  高亢  陈萍  李晓红  马铮
作者单位:首都医科大学附属复兴医院心脏中心,北京,100038
基金项目:北京市西城区优秀人才培养专项经费资助课题(No:20100027)
摘    要:目的:观察接受经皮冠状动脉介入治疗(PCI)的非ST段抬高急性冠脉综合征(NST-ACS)患者炎症反应与造影剂肾病(CIN)的关系。方法:239例NST-ACS患者根据是否并发全身炎症反应综合征(SIRS)分为SIRS组(n=68)及非SIRS对照组(n=171)。两组患者均行PCI,观察PCI术前及术后3天两组患者超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、中性粒细胞明胶酶脂质运载蛋白(NGAL)水平和CIN发生率。结果:术前,SIRS组hs-CRP和IL-6高于对照组(P<0.01),两组患者NGAL无明显差异(P>0.05)。术后3天,两组患者hs-CRP及IL-6均较术前降低,NGAL较术前升高,差异均有统计学意义(P<0.01)。SIRS组hs-CRP、IL-6及NGAL均高于对照组(P均<0.01)。SIRS组CIN发生率高于对照组(P<0.05)。结论:接受PCI治疗NST-ACS患者体内炎症反应可能是导致CIN发生的因素之一。NGAL可能不是CIN发生的影响因素。

关 键 词:造影剂肾病  全身炎症反应综合征  非ST段抬高急性冠脉综合征  经皮冠状动脉介入治疗

Influence of Inflammatory Response to Contrast-induced Nephropathy in Patients with NST-ACS Undergoing Percutaneous Coronary Intervention
Liang Haifeng, Yang Ming, Han Ling, Gao Kang, Chen Ping, Li Xiaohong, Ma Zheng. Influence of Inflammatory Response to Contrast-induced Nephropathy in Patients with NST-ACS Undergoing Percutaneous Coronary Intervention[J]. Chinese Journal of Microcirculation, 2013, 23(1): 21-23,5,1
Authors:Liang Haifeng   Yang Ming   Han Ling   Gao Kang   Chen Ping   Li Xiaohong   Ma Zheng
Affiliation:Cardiology Center,Fuxing Hospital Affiliated to Capital Medical University,Beijing 100038,China;
Abstract:Objective: To observe the association between inflammatory response and contrast-induced nephropathy in patients with NST-ACS undergoing percutaneous coronary intervention. Method: A total of 239 patients with NST-ACS were assigned to two groups according to systemic inflammatory response syndrome(SIRS): SIRS group(n=68) and control group(n=171).hs-CRP, IL-6, NGAL at pre-stenting and 3 days post-stenting were detected. Moreover, the incidence rate of contrast-induced nephropathy was monitored. Results: At pre-stenting, the hs-CRP and IL-6 in SIRS group were significantly higher than control group(P<0.01). The NGAL was no significant different in two groups(P>0.05). At 3 days post-stenting, the hs-CRP and IL-6 in two groups were lower than pre-stenting(P<0.01). The NGAL in two groups were higher than pre-stenting(P<0.01). At 3 days post-stenting, the hs-CRP,IL-6 and NGAL in SIRS group were significantly higher than control group(P<0.01).The accidence rate of contrast-induced nephropathy in SIRS group was significantly higher than control group. Conclusion: The inflammatory response may be a factor of contrast-induced nephropathy in patients with NST-ACS undergoing percutaneous coronary intervention. The NGAL may be not an influential factor of contrast-induced nephropathy.
Keywords:Contrast-induced nephropathy   Systemic inflammatory response syndrome   non-ST segment elevation acute coronary syndrome   Percutaneous coronary intervention
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