| 人尿中美沙芬及其代谢产物的气—质联用分析 |
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| 引用本文： | 徐友宣,申利,张长久.人尿中美沙芬及其代谢产物的气—质联用分析[J].药学学报,1993,28(2):156-159. |
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| 作者姓名： | 徐友宣 申利 张长久 |
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| 作者单位： | 国家体委运动医学研究所兴奋剂检测中心，国家体委运动医学研究所兴奋剂检测中心，国家体委运动医学研究所兴奋剂检测中心 北京 100029，北京 100029，北京 100029 |
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| 摘 要： | A GC-MS method for the analysis of dextromethorphan and its metabolites is described. The urine sample was hydrolyzed with HCl, extracted with diethyl ether and derivatized with MSTFA (N-methyl-N-trimethylsilyltrifluoroacetamide)-MBTFA (N-methyl-bistrifluoroacetamide). Dextromethorphan and its 3 metabolites were detected in urine samples within 2～60 h after administration of the drug. Their structures and the variation of their concentration in urine were determined. The detection limit of dextromethorphan is 10 ng.
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| 关 键 词： | 美沙芬 化谢物 GC—MS |
| 收稿时间： | 1992-06-03 |
ANALYSIS OF DEXTROMETHORPHAN AND ITS METABOLITES IN HUMAN URINE BY USING GAS CHROMATOGRAPHY-MASS SPECTROMETRY |
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| YX Xu,L Shen and CJ Zhang.ANALYSIS OF DEXTROMETHORPHAN AND ITS METABOLITES IN HUMAN URINE BY USING GAS CHROMATOGRAPHY-MASS SPECTROMETRY[J].Acta Pharmaceutica Sinica,1993,28(2):156-159. |
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| Authors: | YX Xu L Shen and CJ Zhang |
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| Abstract: | A GC-MS method for the analysis of dextromethorphan and its metabolites is described. The urine sample was hydrolyzed with HCl, extracted with diethyl ether and derivatized with MSTFA (N-methyl-N-trimethylsilyltrifluoroacetamide)-MBTFA (N-methyl-bistrifluoroacetamide). Dextromethorphan and its 3 metabolites were detected in urine samples within 2～60 h after administration of the drug. Their structures and the variation of their concentration in urine were determined. The detection limit of dextromethorphan is 10 ng. |
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| Keywords: | Dextromethorphan Metabolite GC-MS |
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