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Serum 25-hydroxyvitamin D concentrations in obese and non-obese women with polycystic ovary syndrome
Authors:Recep Yildizhan  Mertihan Kurdoglu  Ertan Adali  Ali Kolusari  Begum Yildizhan  Hanim Guler Sahin  Mansur Kamaci
Affiliation:(1) Department of Obstetrics and Gynecology, School of Medicine, Yuzuncu Yil University, Van, Turkey;(2) Department of Obstetrics and Gynecology, School of Medicine, Marmara University, Istanbul, Turkey;(3) Cemil Topuzlu C. 103/15, Caddebostan, 34728 Istanbul, Turkey
Abstract:Purpose  To investigate the correlation between serum 25-hydroxyvitamin D (25-OH-VD) concentrations and metabolic parameters in obese and non-obese women with polycystic ovary syndrome (PCOS). Methods  One hundred women with PCOS were divided into two groups, obese and non-obese, according to their body mass index (BMI). Waist-to-hip ratio (WHR), Ferriman–Gallwey score, homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol, triglycerides, calcium, 25-OH-VD, LH/FSH, total testosterone, and DHEAS were measured. Results  The serum 25-OH-VD mean levels were 56.31% lower in the obese PCOS patients. There was an association of increased HOMA-IR, BMI, WHR, triglycerides, total testosterone, and DHEAS with decreased 25-OH-VD concentrations in the obese PCOS patients. Conclusion  Low serum 25-OH-VD concentrations result from the presence of obesity and insulin resistance. However, the dependency between PCOS and hypovitaminosis D is questionable. Hypovitaminosis D should be kept in mind while managing obese women with PCOS.
Keywords:Polycystic ovary syndrome  25-Hydroxyvitamin D  Insulin resistance  Obese  Non-obese
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