| 普卡必利的合成 |
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| 引用本文： | 刘 宇,夏 超,刘 媛. 普卡必利的合成[J]. 药学与临床研究, 2011, 19(4): 306-307 |
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| 作者姓名： | 刘 宇 夏 超 刘 媛 |
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| 作者单位： | 南京工业大学,江苏省药物研究所有限公司,南京,210009 |
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| 摘 要： | 改进普卡必利的合成工艺,以对乙酰胺基水杨酸甲酯为起始,经烃化、重排、氧化、还原、环合、氯化、水解、酰化8步制得.总收率达27.6%.
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| 关 键 词： | 普卡必利 合成 肠蠕动药 |
| 收稿时间： | 2011-05-30 |
| 修稿时间： | 2011-06-03 |
Synthesis of Prucalopride |
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| LIU Yu,XIA Chao and LIU Yuan. Synthesis of Prucalopride[J]. Pharmacertical and Clinical Research, 2011, 19(4): 306-307 |
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| Authors: | LIU Yu XIA Chao LIU Yuan |
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| Affiliation: | LIU Yu,XIA Chao,LIU Yuan Jiangsu Province Institute Limited Corporation of Materia Medica,Nanjing University of Technology,Nanjing 210009,China |
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| Abstract: | This study is to synthesize prucalopride and optimize the process.Prucalopride was synthesized by steps of alkylation,rearrangement,oxidation,reduction,cyclization,chlorination,hydrolysis and acylation,with an overall yield of 27.6%. |
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| Keywords: | Prucalopride Synthesis Enterokinesia drug |
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