| 奥曲肽抑制人卵巢癌细胞增殖 |
| |
| 引用本文： | 张云霞,任慕兰.奥曲肽抑制人卵巢癌细胞增殖[J].江苏医药,2011,37(10). |
| |
| 作者姓名： | 张云霞 任慕兰 |
| |
| 作者单位： | 东南大学附属中大医院妇产科,南京市,210009 |
| |
| 摘 要： | 目的 探讨生长抑素类似物奥曲肽在体内外对人卵巢癌细胞株SKOV3生长的影响.方法 Mtt比色法观察体外奥曲肽对人卵巢癌细胞株SKOV3的生长抑制作用.建立人卵巢癌细胞株SKOV3裸鼠移植瘤模型,随机分成四组,分别给予生理盐水(A组)、奥曲肽(B组)、顺铂(C组)及两药联用(D组)处理,处死裸鼠后采用免疫组织化学法检测肿瘤标本血管内皮生长因子(VEGF)的表达.结果 奥曲肽可抑制体外SKOV3细胞生长,且其作用呈时间、浓度依赖性.各用药组瘤重、瘤体积、VEGF的表达均低于A组(P<0.05).结论 奥曲肽能抑制体内外人卵巢癌细胞株SKOV3生长,对肿瘤VEGF表达的抑制可能为其抑瘤机制之一.
|
| 关 键 词： | 奥曲肽 卵巢癌 血管内皮生长因子 |
Octreotide inhibits the growth of human ovarian cancer cell line |
| |
| ZHANG Yunxia,REN Mulan.Octreotide inhibits the growth of human ovarian cancer cell line[J].Jiangsu Medical Journal,2011,37(10). |
| |
| Authors: | ZHANG Yunxia REN Mulan |
| |
| Institution: | ZHANG Yunxia,REN Mulan.Affiliated Zhongda Hospital,Southeast University,Nanjing 210009,CHINA |
| |
| Abstract: | Objective To study the effect of octreotide(OCT) on the growth of human ovarian cancer cell line SKOV3 in nude mice in vivo and in vitro.Methods The inhibitory effects of octreotide on SKOV3 were studied using MTT tecnique in vitro.Xenograft model of human ovarian cancer was established by implantation of SKOV3 into nude mice.Animals were randomly divided into 4 groups of A(normal saline),B(octreotide),C(cDDP) and D(octreotide plus cDDP).The mice were killed and VEGF expression of xenograft was detected by ... |
| |
| Keywords: | Octreotide Ovarian cancer Vascular endothelial growth factor |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
