| 糖尿病肾病患者血清PECAM-1的表达及临床意义 |
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| 引用本文： | 王兴纬,金星进,沈晓伟,奚正荣,陆益龙,巴荣,侯莉,雷艳花,陈霞.糖尿病肾病患者血清PECAM-1的表达及临床意义[J].江苏医药,2011,37(10). |
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| 作者姓名： | 王兴纬 金星进 沈晓伟 奚正荣 陆益龙 巴荣 侯莉 雷艳花 陈霞 |
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| 作者单位： | 1. 南通大学附属妇幼保健院,226006
2. 江苏大学附属医院 |
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| 摘 要： | 目的 探讨糖尿病肾病(DN)患者血清血小板内皮细胞黏附分子1(PECAM-1)的表达及其临床意义.方法 ELISA法检测20例DN患者(DN组)血清PECAM-1,高效液相法检测糖化血红蛋白(HbA1c),生化法检测血糖(Glu),全血细胞分析仪测定血小板计数(Plt);其结果与19例2型糖尿病患者(T2DM组)及16例正常人(C组)比较.结果 DN组PECAM-1、Glu、HbA1c水平高于C组(P<0.01).T2DM组PECAM-1与Glu、HbA1c水平呈正相关(P<0.01),Glu与HbA1c水平呈正相关(P<0.05).结论 血清PECAM-1高表达是促进T2DM患者血管内皮细胞内皮损伤和肾功能损害的重要因素;血清PECAM-1水平可作为该类疾病治疗效果评价及并发症发生的预测指标..
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| 关 键 词： | 2型糖尿病 糖尿病肾病 血小板内皮细胞黏附分子1 |
Expression and clinical significance of serum PECAM-1 in patients with diabetic nephropathy |
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| WANG Xingwei,JIN Xingjin,SHEN Xiaowei,et al..Expression and clinical significance of serum PECAM-1 in patients with diabetic nephropathy[J].Jiangsu Medical Journal,2011,37(10). |
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| Authors: | WANG Xingwei JIN Xingjin SHEN Xiaowei |
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| Institution: | WANG Xingwei,JIN Xingjin,SHEN Xiaowei,et al.Affiliated Nantong Maternity and Child Health Care Hospital,Nantong University,Nantong 226006,CHINA |
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| Abstract: | Objective To investigate the changes of serum concentrations of platelet endothelial cell adhesion molecule-1(PECAM-1)in type 2 diabetic mellitus(T2DM) patients with diabetic nephropathy(DN).Methods Serum PECAM-1,blood glucose(Glu),glycosylated hemoglobin A-1c(HbA1c) and platelet count(Plt) were examined in 20 DN patients(group DN),19 T2DM patients(group T2DM) and 16 healthy persons(group C).Results The levels of PECAM-1,HbA1c and Glu were higher in group DN than those in group C(P<0.01).In group T2DM,serum... |
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| Keywords: | Type 2 diabetes mellitus Diabetic nephropathy Platelet endothelial cell adhesion molecule-1 |
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