| 噁唑烷酮类抗菌药的研究进展 |
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| 引用本文： | 杨 娜,尤启冬. 噁唑烷酮类抗菌药的研究进展[J]. 药学与临床研究, 2011, 19(4): 332-336 |
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| 作者姓名： | 杨 娜 尤启冬 |
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| 作者单位： | 中国药科大学药物化学教研室,南京,210009 |
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| 摘 要： | 噁唑烷酮类化合物是一类新型的治疗细菌性感染的化学全合成药物,并得到了广泛的研究与发展。在Linezolid(利奈唑胺)被美国FDA批准上市后,又有Radezolid(雷得唑来)和Torezolid进入临床研究。本文对近年来噁唑烷酮类抗菌化合物的发展进行了综述,并着重介绍了目前在临床研究的两个噁唑烷酮类抗菌药Radezolid和Torezolid。
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| 关 键 词： | 噁唑烷酮 抗菌活性 利奈唑胺 雷得唑来 |
| 收稿时间： | 2011-04-13 |
| 修稿时间： | 2011-05-22 |
Developments of Novel Oxazolidinone Antibacterial Agents |
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| YANG Na and YOU Qi-dong. Developments of Novel Oxazolidinone Antibacterial Agents[J]. Pharmacertical and Clinical Research, 2011, 19(4): 332-336 |
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| Authors: | YANG Na and YOU Qi-dong |
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| Affiliation: | YANG Na,YOU Qi-dong Department of Medicinal Chemistry,China Pharmaceutical University,Nanjing 210009,China |
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| Abstract: | Linezolid is the first member in a new class of synthetic antibacterial agents known as oxazolidinones.Since its launch in 2000,various modifications have been carried out on the scaffold.New structures with the antibacterial spectrum enlarged and the antibacterial activity improved,and their clinical developments are reviewed in this paper. |
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| Keywords: | Oxazolidinones Antibacterial activity Linezolid Radezolid |
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