| HBx在原发性肝细胞癌致病机制中的作用 |
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| 引用本文： | 邵冰,杨佳琦,曹博,王巨,张华萍,王滨有. HBx在原发性肝细胞癌致病机制中的作用[J]. 疾病控制杂志, 2011, 15(3): 241-245 |
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| 作者姓名： | 邵冰 杨佳琦 曹博 王巨 张华萍 王滨有 |
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| 作者单位： | 1. 哈尔滨医科大学公共卫生学院流行病学教研室,黑龙江,哈尔滨,150086
2. 哈尔滨医科大学预防保健医院,黑龙江哈尔滨,150001 |
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| 摘 要： | 原发性肝细胞癌(hepatocellular carcinome,HCC)是一种常见的恶性疾病,病死率较高,乙型肝炎病毒(hepatitis B virus,HBV)的感染是其发生的最主要原因之一,而其X基因编码的HBx蛋白可以通过与细胞周期相关因子、p53基因、细胞DNA、中心体、线粒体等相互作用而导致HCC的发生.通过对HBx的研究有助于阐明HBV相关肝细胞癌的发病机制,从而为肝癌的治疗和药物的研发提供理论依据.
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| 关 键 词： | 癌,肝细胞 HBx蛋白 致病机制 |
The pathogenic mechanism of HBx in primary hepatocellular carcinoma development |
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| SHAO Bing,YANG Jia-qi,CAO Bo,WANG Ju,ZHANG Hua-ping,WANG Bin-you. The pathogenic mechanism of HBx in primary hepatocellular carcinoma development[J]. Chinese Journal of Disease Control and Prevention, 2011, 15(3): 241-245 |
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| Authors: | SHAO Bing YANG Jia-qi CAO Bo WANG Ju ZHANG Hua-ping WANG Bin-you |
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| Affiliation: | SHAO Bing1,YANG Jia-qi1,CAO Bo1,WANG Ju2,ZHANG Hua-ping2,WANG Bin-you1.1.Department of Epidemiology,School of Public Health,Harbin Medical University,Harbin 150086,China,2.Preventive Health Care Hospital of Harbin Medical University,Harbin 150001 |
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| Abstract: | The hepatocellular carcinoma(HCC) is a kind of malignant disease.Its mortality is higher.Hepatitis B virus(HBV) infection is the main reason of its occurrence.One of its X gene encoding HBx proteins can interact with the cell cycle related factors,p53gene,DNA,centrosome,mitochondria.Such interaction caused the occurrence of HCC.Research on HBx can help to elucidate the pathogenesis of HBV related HCC,Thus to provide theory for treatment of liver cancer and development of drugs which treat liver cancer. |
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| Keywords: | Carcinoma hepatocellular Hepatitis B virus X protein Pathogenic mechanism |
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