乳腺癌间质血管密度和肿瘤细胞增殖活性及转移预测的研究

目的 :研究乳腺癌新生间质血管密度、肿瘤细胞增殖活性与临床指标间的相互关系 ,为临床判定肿瘤转移及预后提供新的指标。方法 :采用免疫组化方法对 31例乳腺癌进行了间质血管密度、肿瘤细胞增殖活性的检测。结果 :乳腺癌间质血管密度在淋巴结转移阳性者与淋巴结转移阴性者之间具有显著性差异 (P<0 .0 1 ) ;肿瘤细胞增殖活性随乳腺癌组织学级别的增高而增加 ;乳腺癌肿瘤细胞增殖活性随间质血管密度的增加而具有增高的趋势。结论 :乳腺癌间质血管密度及细胞增殖活性可以成为临床判定转移和预后的指标

Study on interstitial vascular density,proliferative activity of tumor cells in breastcancer and the metastatic calculation

? Objective:To study the relationship between the stromal vascular density in breast cancer, proliferative activity of tumor cells and clinical parameter will provide a new indicator that can determine tumor metastasis and prognosis.Methods:To investigate the stromal vascular density and proliferative activity of tumorcells in31 breastcancerby immunohistochemistry stain.Results:1 The stromal vascular density was significantly different between patients with lymph node metastasis and those without lymph node metastasis(P<0 .0 1 ) . 2 The proliferative activity of tumor cells increased with its histological grade.3The proliferative activity of tumor cells in breast cancer showed a tendency to increase with stromal vascular density. Conclusion:The stromal vascular density in breast cancer and proliferative activity of tumor cells willl become an indicator to determine metastasis and prognosis in clinic. 〔