| 止消通脉宁对糖尿病大鼠肾小球细胞外基质成分的影响 |
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| 引用本文： | 王耀献,周建华,赵进喜.止消通脉宁对糖尿病大鼠肾小球细胞外基质成分的影响[J].北京中医药大学学报,2000,23(6):38-39. |
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| 作者姓名： | 王耀献 周建华 赵进喜 |
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| 作者单位： | 北京中医药大学东直门医院!北京100700(王耀献，赵进喜，魏民，吕仁和)，河南省驻马店市第二人民医院!河南463000(周建华) |
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| 摘 要： | 采用链脲佐菌素 (STZ)腹腔注射建立糖尿病大鼠模型 ,观察中药复方止消通脉宁对其肾小球细胞外基质 (ECM)成分的影响。结果显示 :止消通脉宁能够明显减少糖尿病大鼠肾小球ECM主要成分ColIV、FN、LN的积聚 ,具有抑制ECM增生的作用 ,从而可以延缓糖尿病肾病发生发展的病理进程
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| 关 键 词： | 止消通脉宁 实验性糖尿病 肾小球细胞外基质成分 免疫组织化学 半定量分析 大鼠 |
Effects of Zhixiotongmaining Granules on the Components of Glomerular Extracellular Matrix in Diabetic Rats |
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| Wang Yaoxian,Zhou Jianhua,Zhao Jinxi,et al..Effects of Zhixiotongmaining Granules on the Components of Glomerular Extracellular Matrix in Diabetic Rats[J].Journal of Beijing University of Traditional Chinese Medicine,2000,23(6):38-39. |
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| Authors: | Wang Yaoxian Zhou Jianhua Zhao Jinxi |
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| Abstract: | The effects of Zhixiaotongmaining Granules (ZG) on the components of glomerular extracellular matrix (ECM) were observed in the rats with diabetes induced by streptozotocin. The results showed that ZG could significantly decrease the accumulation of the type IV collagen, fibronectin and laminin, and inhibit ECM proliferation. The results imply that ZG can delay the onset and development of diabetic nephropathy. |
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| Keywords: | Zhixiaotongmaining Granules Experimental Diabetes Components of Glomerular Extracellular Matrix Immunohistochemistry Semi-quantitative Analysis Rat |
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