母体麻疹抗体与婴儿麻疹发病关系的研究

目的探讨母体麻疹抗体与婴儿麻疹发病关系,为降低婴儿麻疹发病,提供科学依据。方法对枣庄市1999-2011年婴儿麻疹发病状况及采用酶联免疫吸附实验(enzyme-linked immunosorbent assay,ELISA)对母体、婴儿、育龄妇女麻疹抗体调查分析。采用SPSS 11.5软件统计分析,分析方法采用χ2检验、t检验、F检验,以P<0.05为差异有统计学意义。结果 1999-2011年共发生麻疹1 485例,婴儿占38.45%;其中<8月龄占23.10%。2004年前(1999-2004年)后(2005-2011年),<8月龄婴儿麻疹所占比例分别为4.46%和30.59%;婴儿平均发病月龄分别为9.38月和7.65月,差异均有统计学意义(χ2=23.62、t=2.74,P均<0.01)。育龄妇女麻疹几何平均倒数滴度(GMRT)2001年最高,为675.50,2009年最低,为370.23;各年份间差异有统计学意义(F=10.78,P<0.01)。婴儿麻疹抗体阳性率、GMRT,2005和2009年6月龄与1999年8月龄相当,差异均无统计学意义(χ2=0.36、t=1.21,P均>0.05)。婴儿患与未患麻疹,其母体抗体阳性率、GMRT分别为79.88%,373.63;86.48%,510.85,差异均有统计学意义(χ2=5.44,P<0.05;t=4.21,P均<0.01)。结论母体麻疹抗体与婴儿麻疹密切相关,随母传麻疹抗体的提前消失婴儿发病月龄趋于前移。因此,提高母体麻疹抗体水平,是控制婴儿麻疹的根本措施。

Study on the relationship between maternal measles antibody and the incidence of infant measles

Objective To explore the relationship between maternal antibodies against measles and the incidence of measles in infants,and to provide the basis for reducing infant measles.Methods To Investigation and analysis of the incidence of measles in infants from 1999 to 2011 in ZaoZhuang and measles antibody of maternal,infant,women of childbearing age by ELISA(Enzyme-linked Immunosorbent Assay).Using the spss11.5 to compile statistics and analysis.The analysis method includeχ2 test,t test and F test.There was statistical significance(P<0.05).Results The cases of measles was 1 485,infant 38.45%,in which < 8-month age 23.10%.Proportion of the<8-month age cases of measles before 2004(from 1999 to 2004)and after 2004(from 2005 to 2011) was 4.46% and 30.59% respectively,and the average Incidence age infants was 9.38 months old and 7.65 months old.The differences were statistically significant(χ2=23.62、t=2.74,P<0.01).Of geometry mean reciprocal titre(GMRT)of women of childbearing age,the highest In 2001 was 675.50,the lowest in 2009 was 370.23,the difference of each year was statistically significant(F=10.78,P<0.01).Of the positive rate of measles in infants,GMRT,6-month age In 2005 and 2009 and 8-month age in 1999 was Equivalent,no difference existed(χ2=0.36、t=1.21,P>0.05).Infants with measles or not,with whose maternal positive rate of antibody,GMRT was 79.88%,373.63,86.48%,510.85,the differences was statistically significant(χ2=5.44,P<0.05;t=4.21,P<0.01).Conclusions Maternal antibodies against measles and measles in infants is closely related,Along with the antibodies against measles from mother advanced disappearing,the month age of infants incidence of measles tended to move forward.So,Improving maternal measles antibody level will be the basic measure of control infant measles.