| 立体定向手术对难治性精神分裂症患者脑脊液多巴胺的影响 |
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| 引用本文： | 刘建新,李拴德,王晓峰,李迎国,宋世田,张宏宾,姜克明.立体定向手术对难治性精神分裂症患者脑脊液多巴胺的影响[J].中国神经精神疾病杂志,2003,29(5):328-329. |
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| 作者姓名： | 刘建新 李拴德 王晓峰 李迎国 宋世田 张宏宾 姜克明 |
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| 作者单位： | 解放军第三医院神经外科研究所,陕西宝鸡,721004 |
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| 基金项目： | 20 0 1年全军医学科研“十五”计划 (A类 )面上基金资助项目(编号 :0 1MA0 19) |
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| 摘 要： | 目的 探讨立体定向手术对难治性精神分裂症患者中枢多巴胺 (DA)代谢的影响。方法 高效液相色谱 电化学检测法 (HPLC ECD)测定 33例立体向手术治疗前后的精神分裂症患者及 30例对照者脑脊液 (CSF)中DA及高香草酸 (HVA)水平。结果 精神分裂症患者手术前CSF中DA、HVA水平显著高于对照组 (P <0 0 5 ) ;手术后DA、HAV水平显著下降 (P <0 0 5 )。结论 立体定向手术能纠正难治性精神分裂症患者中枢DA代谢的紊乱。
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| 关 键 词： | 立体定向手术 难治性精神分裂症 多巴胺 |
| 修稿时间： | 2002年12月20 |
Investigation for CSF levels of DA and HVA in patients with refractory schizophrenia |
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| Liu Jianxin,Li Shuande,Wang Xiaofeng,Li Yingguo,Song Shitian,Zhang Hongbing,Jiang Keming.Investigation for CSF levels of DA and HVA in patients with refractory schizophrenia[J].Chinese Journal of Nervous and Mental Diseases,2003,29(5):328-329. |
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| Authors: | Liu Jianxin Li Shuande Wang Xiaofeng Li Yingguo Song Shitian Zhang Hongbing Jiang Keming |
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| Institution: | Liu Jianxin,Li Shuande,Wang Xiaofeng,Li Yingguo,Song Shitian,Zhang Hongbing,Jiang Keming. Department of Neurosurgery,3ed Hospital,PLA,45 Dongfeng Road,Baoji. 721004. |
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| Abstract: | Objective To study the effect of stereotactic operation on CSF levels of dopamine(DA), homovanillic acid (HVA) in patients with refractory schizophrenia. Methods CSF levels of DA and HVA were detected with high performance liquid chromatography and electrochemical detector. Results CSF levels of DA and HVA were significantly higher ( P<0.05 ) in patients with schizophrenia before operation than that of nomal control. DA and HVA were significantly decreased ( P<0.05 ) after operation in the patients. Conclusions Stereotactic operation could redress central mervous system DA metabolism derangement in patients with refractory schizophrenia. |
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| Keywords: | Stereotactic operation Refractory schizophrenia Dopamine |
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