Effect of CCK-4 on a 35% carbon dioxide challenge in healthy volunteers期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Effect of CCK-4 on a 35% carbon dioxide challenge in healthy volunteers

Authors:	Pols H Griez E Bourin M Schruers K

Affiliation:	^a University of Maastricht, Department of Psychiatry and Neuropsychology,, Maastricht, The Netherlands ^b University of Nantes, Faculty of Medicine, Department of Pharmacology, Nantes, France ^c Academic Anxiety Center, Maastricht, The Netherlands

Abstract:	1. 1. The purpose of this study was to determine whether a subthreshold dose of CCK-4 would enhance the vulnerability of healthy subjects to a 35% carbon dioxide challenge. 2. 2. 27 subjects, with no prior or present psychiatric disorder and in good physical condition were challenged with a vital capacity breath of a 35% carbon dioxide mixture, immediately after an intravenous injection of 5 μg CCK-4 or placebo, according to a random order double blind crossover design. 3. 3. Subjects reported significantly less panic symptoms upon carbon dioxide after premedication with CCK-4 than after placebo. 4. 4. Both CCK-4 and carbon dioxide may act on the same neuronal pathways, but seem to inhibit rather than potentiate each other effects.

Keywords:	carbon dioxide cholecystokinin panic
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