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| 饮食中晚期糖基化终产物对糖尿病肾病大鼠肾脏的损害作用 | |
| 引用本文： | 毕铭霞,朱彬,张瑞斌,逄曙光.饮食中晚期糖基化终产物对糖尿病肾病大鼠肾脏的损害作用[J].山东大学学报(医学版),2011,49(1):6-9,13. |
| 作者姓名： | 毕铭霞 朱彬 张瑞斌 逄曙光 |
| 作者单位： | 1. 山东大学医学院,济南,250012;山东大学附属济南市中心医院血液净化中心,济南,250013 2. 山东大学附属济南市中心医院血液净化中心,济南,250013 3. 山东大学附属济南市中心医院内分泌科,济南,250013 |
| 摘 要： | 目的 观察饮食中晚期糖基化终产物(AGEs)对糖尿病肾病(DN)大鼠肾脏的影响,探讨其作用机制.方法 SD大鼠40只,随机选取10只为空白对照组,30只大鼠DN模型建立成功,随机分为3组:高AGEs饲料组、低AGEs饲料组及普通饲料组,每组10只.分别于第9周及第13周对各组大鼠进行检测:考马斯亮蓝法测定24 h尿蛋白... |
| 关 键 词： | 晚期糖基化终产物 糖尿病肾病 氧化应激 丙二醛 硒谷胱甘肽过氧化物酶 |
| 收稿时间： | 2010-08-23 |
Damage to the kidney of rats with diabetic nephropathy by high advanced glycation end products in the diet |
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| BI Ming-xia,ZHU Bin,ZHANG Rui-bin,PANG Shu-guang.Damage to the kidney of rats with diabetic nephropathy by high advanced glycation end products in the diet[J].Journal of Shandong University:Health Sciences,2011,49(1):6-9,13. | |
| Authors: | BI Ming-xia ZHU Bin ZHANG Rui-bin PANG Shu-guang |
| Institution: | 1. School of Medicine, Shandong University, Jinan 250012, China; 2. Blood Purification Center, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, China; 3. Department of Endocrinology, Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, China |
| Abstract: | Objective To study the effect of oral advanced glycation end products(AGEs) on rats with diabetic nephropathy(DN) and its mechanism.Methods 10 rats were randomly selected from 40 male Sprague-Dawley rats as the control group.The other 30 rats which developed DN were randomly divided into three groups: the AGEs-rich diet group,the AGEs-poor diet group and the common diet group,10 rats in each group.Each group was studied at the 9th and 13th weeks.The following parameters were detected with different methods:... |
| Keywords: | Advanced glycation end products Diabetic nephropathy Oxidative stress Malondialdehyde Se-glutathione peroxidase |
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