中国居民细胞色素P450 2E1基因多态性与胃癌易感性关系的Meta分析

目的探讨中国居民细胞色素P450 2E1(CYP2E1)基因多态性与胃癌易感性的关系。方法检索中国生物医学文献数据库和PubMed，并收集尚未发表的文章及毕业论文，获得有关中国居民CYP2E1基因多态性与胃癌易感性关系的文献进行Meta分析，以病例组和对照组CYP2E1基因型分布的比值比(OR)为效应指标。对文献进行评价筛选，异质性检验，然后应用Meta分析软件Rev Man4．2对各研究原始数据进行统计处理，计算合并OR值及95％可信区间。结果最终纳入系统评价进行Meta分析的共有6个病例．对照研究，其中胃癌患者881例，对照942例。Meta分析结果合并OR=1．21，95％可信区间为0．70-2．12，说明中国居民CYP2E1基因型频率分布与胃癌的关联无统计学意义。结论对目前相关研究结果的Meta分析显示尚无足够的证据证明中国居民CYP2E1基因多态性与胃癌易感性之间的关系，有必要开展更多设计实施良好的研究，将研究结果纳入该系统评价Meta分析以解决这一问题。

Meta-analysis on the Relationship between Genetic Polymorphism of Cytochrome P450 2E1 and the Susceptibility to Gastric Cancer in Chinese

Objective To study the relationship between Cytochrome P450 2E1 genetic polymorphism and susceptibility to gastric cancer in Chinese by means of Meta-analysis. Methods Literature searches in CBMdisc and PubMed were carried out to find relevant papers, and unpublished data were also collected. Odds ratio of CYP2E1 genotype distributions in patients with gastric cancer against healthy control was calculated. The Meta-analysis was applied with RevMan4.2 software for heterogeneity test and pooled OR calculation. Results Of the 6 case-control studies selected for this Meta-analysis, a total of 881 gastric cancer cases and 942 controls were included. The pooled odds ratio of CYP2E1 genotype C1/C1 vs C1/C2 C2/C2 was 1.21(95%CI 0.70-2.12). Conclusion There was not enough evidence currently and further more studies were needed to prove the relationship between CYP2E1 genetic polymorphism and susceptibility to gastric cancer in Chinese residents.