全反式维甲酸与三氧化二砷治疗急性早幼粒细胞白血病疗效观察

目的：探讨全反式维甲酸(ATRI)与三氧化二砷(As2O3)并用治疗7例初治急性早幼粒细胞白血病(APL)的疗效及副反应。方法：7例采用ATRI 30mg--60mg／d，0．1％As2O3 10mg溶于15％葡萄糖500ml持续滴注3—4小时，30天为1疗程。结果：7例中6例于34天左右CR，未出现明显高白细胞综合症及维甲酸综台症，肝肾损害轻，无病生存期长，结论：ATRI与As2O3并用治疗初治APL疗效好，副反应少，无病生存期长。

Observation for Effects of All-trans Retinoic Acid Combined With Arsenic Trioxide on Acute Promyelocyte Leukemia

Objective To explore effects and side-effect of all-trans retinoic (ATRA) combined with arsenic trioxide on initital acute promyelocyte leukemia(APL) . Methods 7 cases of APL were treated with ATRA and arsenic trioxide, ATRA was given by 30mg - 60mg per day (10mg tid - 20mg tid), and 0.1% arsenic trioxide 10mg administered by intravenous in 500 ml 5 % glucose solution for 3 to 4 hours perday, 30 days as a course. Results 6 cases were complete remission, without hyper-leucocutemia syndrome and retinoic acid syndrome. Hepatic and renal damages were sh'ght in them. Their free-illness surviving period is longer. Conclusion It displays good-effect, little side-effect and longer free-illness surviving period that ATRA combined with arsenic trioxide on inital APL.