| 羟丙基甲基纤维素对水溶性药物释放的影响 |
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| 引用本文： | 杨红军,陆彬.羟丙基甲基纤维素对水溶性药物释放的影响[J].华西药学杂志,1997,12(3):148-150. |
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| 作者姓名： | 杨红军 陆彬 |
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| 作者单位： | 华西医科大学药学院!成都，610041，华西医科大学药学院!成都，610041 |
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| 摘 要： | 以维生素Ｃ为水溶性药物的模型物，三种不同粘度的羟丙基甲基纤维素制成的凝胶骨架片，以Ｋ１００Ｍ规格对维生素Ｃ的释放有延缓作用。维生素Ｃ民羟丙基甲基纤维素的四种不同比例量制成的凝胶骨架片，其中以１：１的比例量，对维生素Ｃ的释放更缓慢。在凝胶骨架片中含有乳糖时，可加快维生素Ｃ的释放。
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| 关 键 词： | 羟丙基甲基 纤维素 维生素C 凝胶骨架片 释放度 |
THE EFFECT OF HYDROXYPROPYLMETHYLCELLULOSE ON THE RELEASE OF A WATER SOLUBLE DRUG |
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| Yang Hong ,Hongjun, Lu Bin.THE EFFECT OF HYDROXYPROPYLMETHYLCELLULOSE ON THE RELEASE OF A WATER SOLUBLE DRUG[J].West China Journal of Pharmaceutical Sciences,1997,12(3):148-150. |
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| Authors: | Yang Hong Hongjun Lu Bin |
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| Abstract: | The effect of drug: ratios viscosity of hydroxypropylmethylcellulose (HPMC) and the presence of lactose on the drug release characteristics from hydrophilic matrix tablets were studied with Vitamin C as a model drug. HPMCK100M could delay the release rate of Vitamin C more efficiently than the other two (HPMC K4M and HPMC K15M). Variation in drug: HPMC ratios from 3: 1 to 1 1 2 could affect the release rate of drug, and the ratio 1: 1 gave the lowest release rate. The presence of lactose in the tablet increased the release rate. |
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| Keywords: | Hydroxypropylmetylcellulose Vitamin C Hydrophilic matrix tablet Higuchi equation |
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