口腔颌面部肿瘤患者T淋巴细胞核仁组成区嗜银蛋白的表达

目的　探讨口腔颌面部肿瘤患者外周血T淋巴细胞核仁组成区嗜银蛋白(Ag-NORs)的表达特点及其在口腔颌面部肿瘤诊断中的价值。方法　采用KL型肿瘤免疫图像分析系统及配套试剂,对86例正常人、102例口腔颌面部良性肿瘤和87例恶性肿瘤患者的外周血T淋巴细胞Ag-NORs进行检测,计算银染核仁面积与细胞核面积的比值(I.S%),然后进行综合分析。结果　口腔颌面部良性肿瘤组患者Ag-NORs表达与正常人组相比明显降低,良性肿瘤组平均I.S%值为(5·72±0·14),正常人组平均I.S%值为(7·87±0·12),两组间有显著性差异(P<0·01);恶性肿瘤组患者Ag-NORs表达降低更为明显,平均I·S%值为(4·19±0·13),与正常人组间有显著性差异(P<0·01);良性肿瘤患者组与恶性肿瘤组之间平均I.S%值也有显著性差异(P<0·01)。结论　外周血T淋巴细胞Ag-NORs表达与口腔颌面部肿瘤呈良好的相关性; Ag-NORs的检测可作为口腔颌面部肿瘤诊断及鉴别诊断的一项重要参考指标。

Expression of Nucleolar Organizer Regions Associated Proteins of T Lymphocytes in the Patients with Oral and Maxillofacial Tumors

OBJECTIVE: To study the Ag-NORs expressive character of T lymphocyte in patients with oral and maxillofacial tumor and evaluate its diagnostic value for the patients. METHODS: Nucleolar organizer regions(NORs) of T lymphocyte from 86 normal adults, 102 patients with oral and maxillofacial benign tumors and 87 patients with oral and maxillofacial malignant tumors were analyzed through KL imaging system. RESULTS: There was significant difference among normal adults, benign and malignant patients (P < 0.01). Their average I.S% values were 7.87 +/- 0.12, 5.72 +/- 0.14, 4.19 +/- 0.13, respectively. CONCLUSION: The expression of Ag-NORs of T lymphocyte has definite relation with oral and maxillofacial tumors; detection of Ag-NORs might play valuable in diagnosis of oral and maxillofacial tumors.