The influence of spontaneous and induced labour on the rise in prostaglandins at amniotomy |
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| Authors: | S M SELLERS M D MITCHELL A B M ANDERSON A C TURNBULL |
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| Institution: | Nuffield Department of Obstetrics and Gynaecology, John Raddiffe Hospital, Headington, Oxford OX3 9DU |
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| Abstract: | Summary. Maternal peripheral plasma levels of 13, 14-dihydro-15-keto-prostaglandin F (PGFM) were measured immediately before and 5 min after amniotomy. Three groups of women were studied: women in late pregnancy; women in spontaneous labour; and women who had received intravaginal prostaglandin E2 (PGE2) pessary. There was no significant difference in the magnitude of the rise in PGFM after amniotomy in late pregnancy or during spontaneous labour suggesting that labour has no influence on the release of prostaglandin F2α (PGF2α) induced by artificial rupture of the fetal membranes. However, local administration of PGE2 before amniotomy caused a greater rise in PGFM suggesting that PGE2 can influence the release and/or metabolism of PGF2α. |
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