慢性肾脏病伴代谢综合征患者大动脉僵硬度水平及相关因素分析

目的：观察慢性肾脏病伴代谢综合征的患者大动脉僵硬度水平以及相关因素，分析其相关性。方法：选择伴有代谢综合征的慢性肾脏病患者共247例，观察及记录其年龄、体重、血压、血糖、血脂等指标，另外测定各例患者颈-股脉搏波速度(CF-PWV)，加以分级，并进行分析。结果：对伴代谢综合征的慢性肾脏病患者中CF-PWV加以分级，血管轻度以上硬化有168例，占患者总数68.0%；单因素分析中CF-PWV与收缩压（SBP）、脉压（PP）呈正相关，有显著统计学意义（P＜0.001），与甘油三酯（TG）、超敏C反应蛋白（sCRP）呈正相关，有统计学意义（P＜0.05），与高密度脂蛋白胆固醇（HDL-C）、白蛋白（Alb）呈负相关，有统计学意义（P＜0.05）；多元逐步回归分析显示，年龄、SBP、PP和HDL-C是影响患者CF-PWV的独立因素，所建立回归方程为CF-PWV（m/s）=2.981 0.025年龄（岁） 0.032SBP（mmHg） 0.044PP（mmHg） 0.230HDL-C（mmol/L），各偏回归系数P＜0.05。结论：伴代谢综合征的慢性肾脏病患者中存在血管硬化的比例明显，CF-PWV与患者年龄、SBP、PP、HDL-C等具有相关性，提示相关客观指标可作为血管硬化程度评价依据，通过一定程度干预血压、血脂等相关因素可能对预防或延缓慢性肾脏病伴代谢综合征患者血管硬化起作用。

Analysis of arterial stiffness and associated factor in Chronic Kidney Disease Patients with Metabolic Syndrome

Objective To observe arterial stiffness, its related risk factors and analyze its correlation in Chronic Kidney Disease Patients with Metabolic Syndrome. Methods We recruited 247 CKD patients with MS, Observe and record?their age, weight,blood pressure,blood glucose,?blood lipid and etc. In addition,?determination of the?patients with?carotid femoral pulse wave velocity?(CF-PWV),?to be?graded?and analyzed. Results Classification of CKD patients with MS?in the CF-PWV,168 patients above?vascular?mild hardening,68% of?the?total. Univariate?analysis?revealed that?CF-PWV?and systolic blood pressure(SBP),?pulse pressure(PP) was positively correlated,there was significant(P<0.001),?and?triglyceride(TG),?high sensitive C reactive protein(sCRP)was positively correlated, with statistical significance(P < 0.05),and high density lipoprotein cholesterol (HDL-C),albumin(Alb)?was negatively correlated,?with statistical significance(P<0.05); Multivariate?regression?analysis?revealed? that CF-PWV was positively and independently associated with age, SBP, PP, and HDL-C, the?regression equation?was CF-PWV?(m/s)?=2.981 0.025 age?(yearsold) 0.032SBP?(mmHg)? 0.044PP?(mmHg)? 0.230HDL-C?(mmol/L),?the?partial regression coefficient of P?< 0.05. Conclusion The?proportion?of?arterial stiffness in CKD patients with MS increased?markedly. CF-PWV related?to?the?patients?age,?SBP, PP HDL-C?and?other?factors.It provides a?important basis for that the relevant objective?index can be used as arterial stiffness?degree . Through a certain degree of?associated factor of blood pressure,?blood lipid?intervention may play a role in preventing?or delaying?arterial stiffness in CKD patients with MS.