| RANKL/RANK/OPG系统与绝经后骨质疏松模型的研究 |
| |
| 引用本文： | 任洁,卢建华.RANKL/RANK/OPG系统与绝经后骨质疏松模型的研究[J].浙江中西医结合杂志,2015,25(9). |
| |
| 作者姓名： | 任洁 卢建华 |
| |
| 作者单位： | 浙江中医药大学第一临床医学院,浙江中医药大学第一临床医学院 |
| |
| 基金项目： | 浙江省自然科学(No.Y206272) |
| |
| 摘 要： | <正>绝经后骨质疏松症(postmenopausal osteoporosis,PMOP)是指绝经后的妇女由于卵巢功能减退,雌激素不分泌或者分泌过少,骨吸收大于骨形成,形成高转化型的骨质疏松特点。临床研究1-2]发现:60岁的女性发病率高达24%,中老年女性诊断为骨质疏松是男性的3倍。绝经后骨质疏松模型是通过切除动物的卵巢,造成雌激素分泌减少,来模拟PMOP。雌激素的减少破坏了骨吸收和骨形成的平衡,而
|
| 关 键 词： | RANKL/RANK/OPG 绝经后骨质疏松 护骨素 MiR-503 肿瘤坏死因子-а |
| 收稿时间： | 2015/1/18 0:00:00 |
| 修稿时间： | 2015/1/18 0:00:00 |
The study on RANKL/OPG/RANK system and model of postmenopausal osteoporosis |
| |
| Abstract: | RANKL/OPG/RANK system and postmenopausal osteoporosis in development are closely related. In bone resorption regulating, RANKL/OPG/RANK system can identify different cell regulatory factors, which affect osteoclast formation, differentiation and maturation.In recent years, a large number of RANKL/OPG/RANK system studies are focused on postmenopausal osteoporosis model. In this paper, the model of postmenopausal osteoporosis, RANKL/OPG/RANK system and its related cytokines are summarized. |
| |
| Keywords: | |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《浙江中西医结合杂志》浏览原始摘要信息 |
| 点击此处可从《浙江中西医结合杂志》下载免费的PDF全文 |
|
