Oct4与EGFR在右半结肠癌组织中表达的相关性及临床价值

目的:探讨Oct4与EGFR在右半结肠癌组织中表达的相关性及临床价值.方法:应用免疫组织化学法检测120例右半结肠癌组织中Oct4与EGFR的表达,并与病理参数进行相关性分析;结合GEPIA数据库结果确认两者相关性.结果:免疫组化染色结果显示,Oct4表达与组织学分级、淋巴结转移以及TNM分期呈正相关(P＜0.05),...

Correlation and clinical roles of Oct4 and EGFR in right-sided colon cancer tissue

Objective:To investigate the correlation and clinical value of Oct4 and EGFR in right-sided colon cancer.Methods:Expressions of Oct4 and EGFR in 120 cases of right-sided colon cancer were detected by immunohistochemistry and the relationship of pathological parameters were analyzed.The correlation between Oct4 and EGFR was confirmed through immunohistochemistry and the GEPIA database.Results:Immunohistochemical staining showed that Oct4 expression was positively correlated with histological grade,lymph node metastasis and TNM stage(P<0.05),while EGFR was positively correlated with tumor diameter,histological grade and TNM stage(P<0.01).According to the immunohistochemical score,the EGFR positive expression rate was 50.0%(26/52)in the positive expression of Oct4,while the EGFR positive expression rate was only 29.41%(20/68)in the negative expression of Oct4.Combined with the analysis of the GEPIA database,it was confirmed that Oct4 was positively correlated with EGFR.In addition,26 cases both with Oct4 and EGFR positive in were positively correlated with tumor diameter,histological grade,lymph node metastasis and TNM stage(P<0.05).Conclusion:There is a positive correlation between Oct4 and EGFR in the right-side colon cancer.The combined detection of Oct4 and EGFR could make up the deficiency of clinical pathology diagnosis and provide a new theoretical basis for the exploration of targeted therapy for the right-side colon cancer.