| 赖氨葡锌颗粒含量测定方法的修订 |
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| 引用本文： | 何晓艳,王蓉蓉,肖菁. 赖氨葡锌颗粒含量测定方法的修订[J]. 中国药品标准, 2016, 17(4): 275-278 |
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| 作者姓名： | 何晓艳 王蓉蓉 肖菁 |
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| 作者单位： | 湖南省食品药品检验研究院,湖南省食品药品检验研究院,湖南省食品药品检验研究院 |
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| 摘 要： | 目的：修订赖氨葡锌颗粒现行标准中葡萄糖酸锌的含量测定方法。方法：络合滴定过程中加入氟化铵试剂。结果：葡萄糖酸锌在139.67~259.38mg范围内呈良好的线性关系（r=0.999 5），平均回收率为100.2%，其RSD为0.24% 。结论：修订后的方法消除了辅料蔗糖对含量测定结果的影响，该方法准确度高，可真实反映药品的含量。
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| 关 键 词： | 赖氨葡锌颗粒 葡萄糖酸锌 含量测定 |
| 收稿时间： | 2016-03-24 |
| 修稿时间： | 2016-07-08 |
Revision for the Determination Method of Lysine Hydrochloride and Zinc Gluconate Granules |
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| Affiliation: | Hunan provincial food and Drug Inspection Institute,Hunan provincial food and Drug Inspection Institute and Hunan provincial food and Drug Inspection Institute |
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| Abstract: | Objective: To revise the Assay method of current standard of Lysine Hydrochloride and Zinc Gluconate Granules. Method: Ammonium fluoride reagent was added in the process of complexation titration. Result: Zinc gluconate was linear in the range of 139.67~259.38mg (r=0.999 5), the average recovery was 100.24% with RSD of 0.29%. Conclusion: The modified method can eliminate the influence of sucrose on content determination, which is accurate and can truly reflect the actual content of drug. |
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| Keywords: | Lysine Hydrochloride and Zinc Gluconate Granules |
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