利奈唑胺治疗耐多药肺结核合并结核性脑膜炎1例临床分析

<正>耐药结核病,尤其是耐多药结核病(1]MDR-TB)为难治性结核病,临床应用利奈唑胺联合其他药物治疗MDR-TB及广泛耐药结核病(XDR-TB)取得较好疗效2],但对其用于耐多药肺结核合并结核性脑膜炎的治疗少见报道。笔者临床采用利奈唑胺治疗MDR-TB合并结核性脑膜炎、并在耐多药方案化疗过程中出现病情恶化患者1例,现结合国内外研究进展进行回顾性分析如下。

The Study of the effects of linezolid in the treatment of a patient with MDR tuberculous and meningitis

OBJECTIVE To investigate the efficacy and safety of linezolid in the treatment of against tuberculous meningitis infection. METHODS Case report and systematic review about linezolid for the treatment of patient with XDR tuberculous and meningitis. RESULTS A patient with MDR tuberculous and meningitis were treated by conventional anti-tuberculous treatment and use of linezolid, 600mg intravenous drip bid. The clinical symptoms, including headache, high fever, and unconsciousness etc, were all relieved. Abnormality of cerebrospinal fluid was improved. And sputum-smear conversion was got. During the period of the 4 months" treatment and 10 months" follow-up, no severe adverse reaction be found. CONCLUSION Linezolid could be used effectively and safely in the treatment of patients with MDR tuberculous and meningitis.