SIRT家族在缺血性脑卒中中作用的研究进展

沉默调节蛋白(sirtuins,SIRT)家族是NAD⁺依赖性赖氨酸去乙酰化酶和ADP核糖转移酶的进化保守家族,调节细胞生理活性。NAD⁺水平在细胞生理活动中是动态变化的,NAD⁺的异常变化会引起各种疾病。SIRT在大脑中具有细胞特异性及细胞器特异性表达,参与多种疾病的发生,如缺血性脑卒中。因此,开发和使用SIRT特异性调节剂可以促进神经保护,有望成为治疗缺血性脑卒中的新靶点。

Advances on the role of SIRT family in ischemic stroke

The SIRT family is an evolutionarily conserved family of NAD⁺-dependent lysine deacetylases and ADP ribose transferases that regulate cell physiological activity. NAD⁺ levels are dynamically changed in the physiological activities of cells, whose abnormal changes can cause various diseases. SIRT has cell-specific and organelle-specific expressions in the brain and is involved in the pathology of many diseases, including ischemic stroke. Therefore, the development and use of SIRT-specific modulators might exhibit neuroprotection effects and is expected to develop a new target for the treatment of ischemic stroke.