柴芍承气汤联合丙氨酰谷氨酰胺对重症急性胰腺炎肠功能恢复的影响

<正>重症急性胰腺炎(severe acute pancreatitis,SAP)是临床上常见的重症急腹症,病情凶险,病程进展快,并发症多,死亡率可高达30%1]。SAP时由于微循环障碍、低血容量、肠道缺血-再灌注损伤,导致肠道黏膜屏障破坏,肠道菌群移位,肠源性炎症介质及内毒素吸收,引起败血症、胰腺坏死感染以及全身炎症反应综合症(SIRS)2]。因此,早期修复肠道黏膜屏障功能可以阻止SAP发展,改善预后。本研究旨在观察

Effect of Chaishao Chengqi Decoction Combined with alanyl-glutamine on intestinal function in patients with severe acute pancreatitis

Objective]To evaluated the effect of Chaishao Chengqi Decoction Combined with alanyl-glutamine on intestinal function in patients with severe acute pancreatitis. Methods]46 patients with severe acute panctratitis were randomly divided into two groups: the controlled group and the treatment group. 23 patients in controlled group received routine therapy, while 23 patients in the treatment group were given additional treatment with Chaishao Chengqi Decoction plus alanyl-glutamine. The duration of abdominal pain and distension, the first time of exhaust and defecation, the length of stay in hosptial, intensive care unit(ICU) transfer rate and case fatality rate were observed, while serum C-reactive protein(CRP), amylase(Amy) and white blood cell count were tested. Results] The duration of abdominal pain and distension, the first time of exhaust and defecation in treatment group were significantly shorter than controlled group(P <0.05). After treatment, compared with controlled group, serum C-reactive protein(CRP),amylase(Amy) and white blood cell count in treatment group were significantly decreased(P <0.05).The length of stay in hospital of treatment group is shorter than that of the controlled group(P <0.05). Conclusion] For the treatment of severe acute pancreatitis, Chaishao Chengqi Decoction Combined with alanyl-glutamine can promote the recovery of intestinal function, reduce the systemic inflammatory response syndrome, thus improve the prognosis of the disease.