GPX3 DNA甲基化在恶性肿瘤发生发展中作用的研究进展

近年来,肿瘤表观遗传学的改变已成为癌症治疗和预防极具吸引力的靶点,其最常见和最广泛的表观遗传途径是DNA甲基化.研究发现,谷胱甘肽过氧化物酶3(glutathione peroxidase 3,GPX3)作为一种硒蛋白在体内具有抗病毒和防治多种恶性肿瘤的作用,GPX3的mRNA和(或)蛋白表达下调甚至沉默与GPX3基因...

Research progress on the role of GPX3 DNA methylation in the development and progression of malignant tumors

In recent years,changes in tumor epigenetics have become attractive targets for cancer treatment and prevention,and the most common and widespread epigenetic pathway is DNA methylation.Studies have found that glutathione peroxidase 3(glutathione peroxidase 3,GPX3)acts as a selenoprotein with antiviral and diverse tumors in vivo,GPX3 mRNA and or down-regulation or even silencing of protein expression is associated with hypermethylation of the GPX3 gene promoter,and down-regulation of GPX3 expression after DNA methylation can reduce the clearance of peroxidation products in the body,which in turn leads to accumulation of peroxide in the body,eventually causing the occurrence and development of tumors.