Gestational diabetes reverses the circadian variation of plasma insulin response to intravenous glucose |
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Authors: | A D Kofinas P J Meis J C Rose |
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Institution: | Department of Obstetrics and Gynecology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27103. |
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Abstract: | Both healthy third-trimester pregnant women and a group of women with gestational diabetes failed to show a difference in glucose clearance rates when given an intravenous glucose bolus at 8 AM compared with 4 PM. The plasma insulin response in the healthy pregnant women was greater at 8 AM. In the diabetic group, the peak insulin response was greater at 4 PM, but it was more prolonged after the 8 AM tests. These alterations in plasma insulin response were especially striking in the subgroup of obese women with gestational diabetes, who demonstrated metabolic differences compared with their nonobese counterparts. |
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Keywords: | Gestational diabetes intravenous glucose tolerance circadian variation plasma insulin responses |
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