石榴皮提取物对高脂血症小鼠抗氧化功能和脂质代谢的影响

目的:探讨石榴果皮提取物对高脂血症小鼠抗氧化功能和脂质代谢的影响,并与果汁提取物相比较。方法:采用高脂饲料喂养C57BL/6J小鼠建立动物模型,观察提取物对抗氧化功能、血脂、肝脏脂类含量以及主动脉壁形态学的影响。结果:石榴果皮提取物可以有效改善抗氧化功能,降低血脂及肝脏脂肪和胆固醇含量,抑制主动脉动脉粥样硬化(AS)早期病变,石榴果汁提取物也有同样作用。结论:石榴果皮提取物能够抑制AS早期病变,可能与提高抗氧化功能、降低血脂有关。

EFFECTS OF POMEGRANATE PEEL EXTRACTS ON ANTIOXIDANT CAPACITY AND LIPID METABOLISM IN HYPERLIPIDEMIC MICE

Objective: To investigate the effects of pomegranate peel extract on antioxidant capacity and lipid metabolism in C57BL/6J mice fed high fat diet in comparison with pomegranate juice extract. Method: The hyperlipidemic model was developed by feeding C57BL/6J mice a high fat diet. The effects of pomegranate peel extract (supplemented in drinking water) on serum FRAP value, paraoxonase(PON), GSH-Px and SOD activities as well as serum and hepatic lipids contents were observed. The morphologic change of aortic walls was also examined. Results: The antioxidant capacity and lipid metabolism were improved by supplementation of pomegranate peel extract in hyperlipidemic mice. The pathologic changes manifested in aortic walls were also inhibited. The pomegranate juice extract presented similar effects. Conclusion: The pomegranate peel extract inhibited the early process of atherosclerosis. The possible mechanisms were related to the improved antioxidant capacity and lipid metabolism.