713株结核分枝杆菌耐药性分析

目的分析2005年以来我中心肺科就诊的肺结核病人结核分枝杆菌耐药趋势，为结核病的防治提供依据。方法应用改良罗氏培养基间接药敏实验绝对浓度法检测结核菌的耐药性情况。结果1754株结核分枝杆菌耐药713株，总耐药率为41．0％；耐多药（MDR）111株，耐多药率为6．3％。耐单药顺位从高到低依次为SM（26．1％）。RFP（25．3％），INH（14．1％），EMB（10．3％）。各年龄组耐药及耐多药均为青年组〉中年组〉老年组。结论结核分枝菌抗药性呈增强趋势，应加强监测，指导防控工作和临床合理用药。

Survey of resistance of 713 Mycobacterium tuberculosis strains to antibiotics

Aim To survey the resistance of Mycobacterium tuberculosis. Methods Drug sensitivity test was carried out by improved L-J culture drug susceptibility test（TB）. Results Among the 1 754 Mycobacterium tuberculosis strains,713 strains were resistance to antibiotics with resistant rate of 41.0%;111 strains were multi-resistan with a rate of 6.3%; The resistance to SM,RFP,INH and EMB were 26.1% ,25.3% , 14.1% and 10.3% respectively. The resistant rate and MDR in young group was higher than that of the middle-aged group and was even higher than that of the senile group. Conclusion The drug resistance of Mycobacterium tuberculosis to antibiotics in Shenzhen show a ncreasing trend and effective measures be adopted .