淋巴细胞间质性肺炎临床病理分析1例并文献复习

目的了解淋巴细胞性间质性肺炎的临床及病理表现。方法1例淋巴细胞性间质性肺炎行开胸肺活检,标本送检病理及免疫组化。结果本病的病理表现主要为受累部位弥漫性间质浸润,显著地肺泡间隔分布,浸润成分大多为T淋巴细胞、浆细胞和巨噬细胞,与支气管黏膜相关的淋巴组织增生常见。结论本病少见,确诊有赖于胸腔镜或开胸肺活检。治疗为类固醇激素,或免疫抑制剂,治疗反应不一。

Lymphoid interstitial pneumonia: A case report and literature review

Objective To examine the clinical and pathological characteristics of lymphoid interstitial pneumonia. Methods Lung biopsy of one case of lymphoid interstitial pneumonia was performed and the data were pathologically studied. Results Main histologic features of LIP included diffusion of interstitial infiltration in infected areas, predominantly showing alveolar septal distribution. Most of the infiltrate elements were T lymphocytes, plasma cells and macrophages. Bronchial mucosa-associated lymphoid tissue (MALT hyperplasia) could be easily identified. Conclusion Lymphoid interstitial pneumonia is a rare disease which can be confirmed through thoracoscopic examination or by open lung biopsy specimens. The first-line of drug treatment of the disease has been corticosteroids, which can also be used for immunosuppressive agents. The responses to these treatments vary.