盐酸吉西他滨配伍卡铂治疗非小细胞肺癌50例临床观察

目的:观察国产盐酸吉西他滨(泽菲)配伍卡铂治疗非小细胞肺癌(NSCLC)的近期疗效及毒副作用。方法:初治NSCLC病例50例,以28d为1周期。采用第1、8天泽菲1.0g/m2,维泵静脉推注,第1天卡铂按AUC=5～6静脉滴注,连用两个周期后评价疗效及毒副作用。结果:全组50例,有效率为44.0%(22/50),主要毒副作用为胃肠反应(Ⅲ～Ⅳ级是6.0%)和血液学毒性,Ⅲ～Ⅳ级白细胞下降和血小板下降分别为10.0%和2.0%。结论:泽菲配伍卡铂治疗NSCLC有较好疗效,毒副作用小,患者耐受性好。

Clinical observation of combination chemotherapy with domestic gemcitabine (ZEFEI) plus carboplatin(CBP) in the treatment of 50 cases of non-small-cell lung cancer

Objective:To observe the short term efficacy and toxicity reactions of domestic gemcitabine(ZEFEI) plus carboplatin(CBP) in the treatment of advanced non-small-cell lung cancer(NSCLC). Methods:50 cases of previously untreated patients with advanced NSCLC were given domestic gemcitabine (ZEFEI) on day 1,8 at a dose of 1.0g/m2 and carboplatin at a dose of AUC=5～6 on day 1. The chemotherapy was repeated every 28 days with two cycles. Results:The response rate was 44.0%(22/50),and the main toxicity reactions were nausea/vomiting(Ⅲ～Ⅳgrade 6.0%) and hematological toxicity,Ⅲ～Ⅳgrade leukopenia and thrombocytopenia were 10.0% and 2.0% respectively. Conclusion:The domestic gemcitabine (ZEFEI) plus carboplatin combination is a highly effective regimen for patients with advanced NSCLC, with a manageable toxicity.