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| 鼻粘膜中一氧化氮合酶表达及其意义 | |
| 引用本文： | 孙家强,王明善,叶非常,刘认华. 鼻粘膜中一氧化氮合酶表达及其意义[J]. 安徽医学, 2006, 27(3): 180-182 |
| 作者姓名： | 孙家强 王明善 叶非常 刘认华 |
| 作者单位： | 230001,合肥,安徽省立医院耳鼻咽喉一头颈外科 |
| 摘 要： | 目的了解正常鼻粘膜中一氧化氮合酶(NOS)的分布特点及活性并分析其在鼻腔中的生理作用。方法用免疫组化法对eNOS、iNOS在20例正常鼻粘膜中表达情况进行对比研究,并用分光光度计法检测NOS活性。结果正常鼻粘膜组中eNOS有表达并分布在粘膜上皮、腺体和血管内皮细胞中,iNOS偶见细胞表达,二者之间差异有显著性(P<0.01)。NOS活性1.526±0.310U/mgPro。结论鼻粘膜中主要表达eNOS,分布在粘膜上皮、腺体和血管内皮细胞中,由其产生的一氧化氮(NO)在鼻腔的正常生理功能中可能起着重要的作用。 |
| 关 键 词： | 鼻粘膜 一氧化氮 一氧化氮合酶 |
| 收稿时间： | 2005-10-13 |
| 修稿时间： | 2005-10-132006-01-04 |
Expression of nitric oxide synthase and its significance in nasal mucosa |
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| Sun Jiaqiang,Wang Mingshan,Ye Feichang,et al. Expression of nitric oxide synthase and its significance in nasal mucosa[J]. Anhui Medical Journal, 2006, 27(3): 180-182 | |
| Authors: | Sun Jiaqiang Wang Mingshan Ye Feichang et al |
| Affiliation: | Sun Jiaqiang,Wang Mingshan,Ye Feichang,et alDepartment of Otolaryngology-Head and Neck Surgery,Anhui Provincial Hospital,Heifei 230001 |
| Abstract: | Objective To study the expression of nitric oxide synthase (NOS) and its activity in nasal mucosa and its significance.Methods Septectomy and immunohistochemisty were used to examine NOS activity and identify the expression of endotheial NOS(eNOS) in human nasal specimens from patients undergoing nasal spectrumtomy (n20).Results eNOS recation product was located in epithelial cell and vascular endothelial cells and nasal glands of nasal mucosa.iNOS reaction product was founded in several cells.Amount of eNOS positive cells was significantly higher than of iNOS positive cells in nasal mucosa (P<0.01).Conclusions eNOS,mainly expressed in nasal mucosa,locates in epithelial cells and vascular endothelial cells and nasal glands in nasal mucosa,which produce NO that plays an important role in nasal mucosa physiology. |
| Keywords: | Nasal mucosa Nitric oxide Nitric oxide synthase |
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