Prenatal detection of cri du chat syndrome on uncultured amniocytes using fluorescence in situ hybridization (FISH) |
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| Authors: | Mark J. Pettenati Rosa Hayworth Kelly Cox P. Nagesh Rao |
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| Affiliation: | Department of Pediatrics, Section on Medical Genetics, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina, USA |
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| Abstract: | Fluorescence in situ hybridization (FISH) with a chromosome-region-specific DNA probe was used prospectively on uncultured amniocyte interphase cells to detect an unbalanced chromosome abnormality that resulted in cri du chat or 5p – syndrome. Confirmation was performed by routine cytogenetics. |
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| Keywords: | cri du chat fluorescence in situ hybridization (FISH) 5p |
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